Pericellular proteolysis in cancer
نویسندگان
چکیده
منابع مشابه
Targeting pericellular proteolysis in vascular disease.
Proteolytic enzymes released from smooth muscle cells (SMCs) degrade extracellular matrix proteins, and this is thought to facilitate cell migration and neointimal thickening in restenosis and vein graft disease. The plasminogen activator (PA) and the matrix metalloproteinase (MMP) systems play important roles mediating these processes. In the PA system, tissue-type plasminogen activator (t-PA)...
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Malignant cells are characterized by high mitogenic activity, disorganized growth, and the ability to invade surrounding normal tissues in vivo. Invasion and metastasis require the release of cells from the restrictive effects of the extracellular matrix, the degradation of basement membranes, the intrusion of malignant cells into connective tissues, and their spread through circulation or lymp...
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To better understand the mechanism of leukocyte migration in complex environments, model extracellular matrices were prepared using gelatin, Hanks' solution, Bodipy-BSA (fluorescent upon proteolysis), and dihydrotetramethylrosamine or hydroethidine (fluorescent upon oxidation). Using quantitative microfluorometry, neutrophil-mediated extracellular pulses of reactive oxygen metabolites (ROMs) an...
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Pericellular proteolysis represents one of the key modes by which the cell can modulate its environment, involving not only turnover of the extracellular matrix but also the regulation of cell membrane proteins, such as growth factors and their receptors. The metzincins are active players in such proteolytic events, and their mode of regulation is therefore of particular interest and importance...
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.......................................................................... 9 Introduction.................................................................... 10 Extracellular matrix........................................................... 10 Interstitial matrix....................................................... 10 Basement membrane................................................... 12 Rol...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2014
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.250647.114